贝叶斯工作流程通常需要引入滋扰参数，但对于核心科学建模，需要访问边缘后部密度。在这项工作中，我们使用掩盖的自回归流量和内核密度估计器封装边缘后部，使我们能够计算边际kullback-leibler脱离器和边缘贝叶斯模型尺寸，此外还可以生成样品和计算边际对数概率。我们将其应用于暗能量调查的局部宇宙学示例和全局21cm信号实验。除了计算边缘贝叶斯统计数据外，这项工作对于在贝叶斯实验设计，复杂的先验建模和似然仿真中进一步应用也很重要。该技术可在PIP可容纳的代码人造黄油中公开获得。

大气效应（例如湍流和背景热噪声）抑制了在开关键控自由空间光学通信中使用的相干光的传播。在这里，我们介绍并实验验证了卷积神经网络，以降低后处理中自由空间光学通信的位错误率，而自由空间光学通信的位比基于高级光学器件的现有解决方案明显简单，更便宜。我们的方法由两个神经网络组成，这是第一个确定在热噪声和湍流中存在相干位序列以及第二个解调相干位序列的存在。通过生成连贯的光线，将它们与热灯结合在一起，并通过湍流的水箱将其结合起来，通过生成开关的键入键流，可以通过实验获得我们网络的所有数据，从而获得了模拟的湍流，并将其传递给了最终的光线。高度准确性。我们的卷积神经网络提高了与阈值分类方案相比的检测准确性，并具有与当前解调和误差校正方案集成的能力。

While the capabilities of autonomous systems have been steadily improving in recent years, these systems still struggle to rapidly explore previously unknown environments without the aid of GPS-assisted navigation. The DARPA Subterranean (SubT) Challenge aimed to fast track the development of autonomous exploration systems by evaluating their performance in real-world underground search-and-rescue scenarios. Subterranean environments present a plethora of challenges for robotic systems, such as limited communications, complex topology, visually-degraded sensing, and harsh terrain. The presented solution enables long-term autonomy with minimal human supervision by combining a powerful and independent single-agent autonomy stack, with higher level mission management operating over a flexible mesh network. The autonomy suite deployed on quadruped and wheeled robots was fully independent, freeing the human supervision to loosely supervise the mission and make high-impact strategic decisions. We also discuss lessons learned from fielding our system at the SubT Final Event, relating to vehicle versatility, system adaptability, and re-configurable communications.

Three main points: 1. Data Science (DS) will be increasingly important to heliophysics; 2. Methods of heliophysics science discovery will continually evolve, requiring the use of learning technologies [e.g., machine learning (ML)] that are applied rigorously and that are capable of supporting discovery; and 3. To grow with the pace of data, technology, and workforce changes, heliophysics requires a new approach to the representation of knowledge.

Much of the information of breathing is contained within the photoplethysmography (PPG) signal, through changes in venous blood flow, heart rate and stroke volume. We aim to leverage this fact, by employing a novel deep learning framework which is a based on a repurposed convolutional autoencoder. Our model aims to encode all of the relevant respiratory information contained within photoplethysmography waveform, and decode it into a waveform that is similar to a gold standard respiratory reference. The model is employed on two photoplethysmography data sets, namely Capnobase and BIDMC. We show that the model is capable of producing respiratory waveforms that approach the gold standard, while in turn producing state of the art respiratory rate estimates. We also show that when it comes to capturing more advanced respiratory waveform characteristics such as duty cycle, our model is for the most part unsuccessful. A suggested reason for this, in light of a previous study on in-ear PPG, is that the respiratory variations in finger-PPG are far weaker compared with other recording locations. Importantly, our model can perform these waveform estimates in a fraction of a millisecond, giving it the capacity to produce over 6 hours of respiratory waveforms in a single second. Moreover, we attempt to interpret the behaviour of the kernel weights within the model, showing that in part our model intuitively selects different breathing frequencies. The model proposed in this work could help to improve the usefulness of consumer PPG-based wearables for medical applications, where detailed respiratory information is required.

With the rise in high resolution remote sensing technologies there has been an explosion in the amount of data available for forest monitoring, and an accompanying growth in artificial intelligence applications to automatically derive forest properties of interest from these datasets. Many studies use their own data at small spatio-temporal scales, and demonstrate an application of an existing or adapted data science method for a particular task. This approach often involves intensive and time-consuming data collection and processing, but generates results restricted to specific ecosystems and sensor types. There is a lack of widespread acknowledgement of how the types and structures of data used affects performance and accuracy of analysis algorithms. To accelerate progress in the field more efficiently, benchmarking datasets upon which methods can be tested and compared are sorely needed. Here, we discuss how lack of standardisation impacts confidence in estimation of key forest properties, and how considerations of data collection need to be accounted for in assessing method performance. We present pragmatic requirements and considerations for the creation of rigorous, useful benchmarking datasets for forest monitoring applications, and discuss how tools from modern data science can improve use of existing data. We list a set of example large-scale datasets that could contribute to benchmarking, and present a vision for how community-driven, representative benchmarking initiatives could benefit the field.

Since early in the coronavirus disease 2019 (COVID-19) pandemic, there has been interest in using artificial intelligence methods to predict COVID-19 infection status based on vocal audio signals, for example cough recordings. However, existing studies have limitations in terms of data collection and of the assessment of the performances of the proposed predictive models. This paper rigorously assesses state-of-the-art machine learning techniques used to predict COVID-19 infection status based on vocal audio signals, using a dataset collected by the UK Health Security Agency. This dataset includes acoustic recordings and extensive study participant meta-data. We provide guidelines on testing the performance of methods to classify COVID-19 infection status based on acoustic features and we discuss how these can be extended more generally to the development and assessment of predictive methods based on public health datasets.

Electronic Health Records (EHRs) hold detailed longitudinal information about each patient's health status and general clinical history, a large portion of which is stored within the unstructured text. Temporal modelling of this medical history, which considers the sequence of events, can be used to forecast and simulate future events, estimate risk, suggest alternative diagnoses or forecast complications. While most prediction approaches use mainly structured data or a subset of single-domain forecasts and outcomes, we processed the entire free-text portion of EHRs for longitudinal modelling. We present Foresight, a novel GPT3-based pipeline that uses NER+L tools (i.e. MedCAT) to convert document text into structured, coded concepts, followed by providing probabilistic forecasts for future medical events such as disorders, medications, symptoms and interventions. Since large portions of EHR data are in text form, such an approach benefits from a granular and detailed view of a patient while introducing modest additional noise. On tests in two large UK hospitals (King's College Hospital, South London and Maudsley) and the US MIMIC-III dataset precision@10 of 0.80, 0.81 and 0.91 was achieved for forecasting the next biomedical concept. Foresight was also validated on 34 synthetic patient timelines by 5 clinicians and achieved relevancy of 97% for the top forecasted candidate disorder. Foresight can be easily trained and deployed locally as it only requires free-text data (as a minimum). As a generative model, it can simulate follow-on disorders, medications and interventions for as many steps as required. Foresight is a general-purpose model for biomedical concept modelling that can be used for real-world risk estimation, virtual trials and clinical research to study the progression of diseases, simulate interventions and counterfactuals, and for educational purposes.

Deep learning classifiers provide the most accurate means of automatically diagnosing diabetic retinopathy (DR) based on optical coherence tomography (OCT) and its angiography (OCTA). The power of these models is attributable in part to the inclusion of hidden layers that provide the complexity required to achieve a desired task. However, hidden layers also render algorithm outputs difficult to interpret. Here we introduce a novel biomarker activation map (BAM) framework based on generative adversarial learning that allows clinicians to verify and understand classifiers decision-making. A data set including 456 macular scans were graded as non-referable or referable DR based on current clinical standards. A DR classifier that was used to evaluate our BAM was first trained based on this data set. The BAM generation framework was designed by combing two U-shaped generators to provide meaningful interpretability to this classifier. The main generator was trained to take referable scans as input and produce an output that would be classified by the classifier as non-referable. The BAM is then constructed as the difference image between the output and input of the main generator. To ensure that the BAM only highlights classifier-utilized biomarkers an assistant generator was trained to do the opposite, producing scans that would be classified as referable by the classifier from non-referable scans. The generated BAMs highlighted known pathologic features including nonperfusion area and retinal fluid. A fully interpretable classifier based on these highlights could help clinicians better utilize and verify automated DR diagnosis.

The General Associative Memory Model (GAMM) has a constant state-dependant energy surface that leads the output dynamics to fixed points, retrieving single memories from a collection of memories that can be asynchronously preloaded. We introduce a new class of General Sequential Episodic Memory Models (GSEMM) that, in the adiabatic limit, exhibit temporally changing energy surface, leading to a series of meta-stable states that are sequential episodic memories. The dynamic energy surface is enabled by newly introduced asymmetric synapses with signal propagation delays in the network's hidden layer. We study the theoretical and empirical properties of two memory models from the GSEMM class, differing in their activation functions. LISEM has non-linearities in the feature layer, whereas DSEM has non-linearity in the hidden layer. In principle, DSEM has a storage capacity that grows exponentially with the number of neurons in the network. We introduce a learning rule for the synapses based on the energy minimization principle and show it can learn single memories and their sequential relationships online. This rule is similar to the Hebbian learning algorithm and Spike-Timing Dependent Plasticity (STDP), which describe conditions under which synapses between neurons change strength. Thus, GSEMM combines the static and dynamic properties of episodic memory under a single theoretical framework and bridges neuroscience, machine learning, and artificial intelligence.